I think the best answer is that Samantha very often has outlier reactions to medications. The last medicine she took for this, Cymbalta (trying to get some restful sleep), subsequently involved a trip to the emergency room. She is understandably very gun-shy over testing out new meds because of this. You need to find a good doctor who is willing to take the time to carefully diagnose both the illness and your wife's specific reactions to medications. Keep your own record of this information because when/if you switch doctors a very common result is that they ignore what has been tried and she will suffer through repetitions of previous failures and/or reactions.
I wish there was a simple answer for you. By the way, Samantha is allergic to tetracycline based medications (referring to minocycline tetracycline). http://www.empr.com/painweek-2013/fibro ... le/310074/
Primary fibromyalgia is more difficult to treat because patients commonly have significant hypersensitivity to the prescribed medications. Better treatment outcomes may result if patients are first subgrouped, possibly on the basis of psychosocial/behavioral or genomic/metabolic characteristics. FDA-approved agents to treat fibromyalgia are pregabalin, a gabapentinoid, and two serotonin–norepinephrine reuptake inhibitors, duloxetine and milnacipran. These drugs should be started low and slowly titrated in patients. In patients with secondary fibromyalgia, the treatment is directed at the primary illness.