My answer would start with a question: how did the customer arrive at these cams specs and CR? If he's been circling in on the optimum cams through many iterations and also finding gains with each increase in CR, then there is nothing to 'fix'; just keep on trucking. (but don't try to get by with 50% pump gas!
)
If the 'tune' came out of thin air or unproven crossover assumptions from a different application, then "too much DCR" would be any number that provoked detonation within the operating rev range on the best available fuel and/or one that lost power Vs. a lower value. It would never be an arbitrary number on a compression gauge.
FWIW, many decades ago a friend of mine bolted a much-milled aluminum head for an 850 cc Mini Minor onto his stock-cammed Morris 1100 (cc). It was a real rocket on Sunoco 280 pump gas (~ 107 Octane, IIRC), but kept blowing head gaskets. After the second one went out, we checked the cranking compression. It pegged the 300# gauge...
BTW, I don't accept the logic of including VE in any discussion of DCR* re a high RPM race engine. (*itself a controversial topic as a stroll through the S/T 'Search' function will reveal) Detonation is a very time-related phenomenon and is far more prevalent at the bottom of a race engine's rev range, normally far below the peak VE. For example, a shop I frequent specializes in 572" to 678" Hemis. Some of his strongest engines run over 16.5:1 CR and produce V.E.s in the high 'one-teens' , but with huge cam durations, have cranking compression in the 165-175# range...
Felix, qui potuit rerum cognscere causas.
Happy is he who can discover the cause of things.